Wakefield’s Hypothesis Verified – again!

Clinical Presentation and Histologic Findings at Ileocolonoscopy in Ch

How many studies will it take before those who deny the proven connection between vaccination and Autism crawl back into the primeval sludge they emerged from? Their stone-age methods of trying to beat those who disagree with them over the head must be stopped. Does yet ANOTHER generation of children have to be destroyed before this connection is acknowledged? The full text of this article is available for free at the link above.
Clinical Presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic Spectrum Disorder and Chronic Gastrointestinal Symptoms

Authors: Arthur Krigsman, Marvin Boris, Alan Goldblatt and Carol Stott
Publication Date: 27 Jan 2010
Autism Insights 2010:2 1-11

Arthur Krigsman1, Marvin Boris2, Alan Goldblatt3 and Carol Stott4

1Assistant Professor of Pediatrics, New York University School of Medicine Director of Gastroenterology Services, Thoughtful House Center for Children, 3001 Bee Caves Rd, Austin, Texas, 78746, USA. 2Associate Clinical Professor of Pediatrics, New York University School of Medicine, 550 1st Ave., New York, NY 10016, USA. 3Adjunct Professor Touro College, 27-33 West 23rd St, New York, NY 10010, USA. 4Thoughtful House Center for Children, 3001 Bee Caves Rd, Austin, Texas, 78746, USA.


Background:  Children with developmental disorders experience chronic gastrointestinal symptoms.

Aims:  To examine the nature of these gastrointestinal symptoms and histologic findings in children with autism spectrum/developmental disorders and ileocolonic disease.

Methods:  Chart review. 143 autism spectrum/developmental disorder patients, with chronic gastrointestinal symptoms, undergoing diagnostic ileocolonoscopy.

Results:  Diarrhea was present in 78%, abdominal pain in 59% and constipation in 36%. Ileal and/or colonic lymphonodular hyperplasia (LNH), defined as the presence of an increased number of enlarged lymphoid follicles, often with hyperactive germinal centers, was present in 73.2%. Terminal ileum LNH presented visually in 67% and histologically in 73%. Colonic LNH was multifocal and presented histologically in 32%. Ileal and/or colonic inflammation presented in 74%, consisting primarily of active or chronic colitis (69%). Ileal inflammation presented in 35%. Presence of LNH significantly predicted mucosal inflammation. Patients with ileal and/or colonic LNH had lower mean/median age than those without; patients with ileal and/or colonic inflammation had lower mean/median age than those without. There was a significant association between ileo and/or colonic inflammation or LNH, and onset of developmental disorder; plateaued or regressive onset conferred greater risk than early onset.

Conclusions:  Patients with autism or related disorders exhibiting chronic gastrointestinal symptoms demonstrate ileal or colonic inflammation upon light microscopic examination of biopsy tissue. Further work is needed to determine whether resolution of histopathology with appropriate therapy is accompanied by GI symptomatic and cognitive/behavioral improvement.

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4 Responses to Wakefield’s Hypothesis Verified – again!

  1. Xavier says:

    I don’t get it. What has this article got to do with vaccination?

    • shotinfo says:

      I don’t think you have read any of the information from Wakefield and the dozens of other researchers who, since 1998, have stated that vaccines can cause the gut issues which then lead to autism spectrum symptoms. This article shows those same symptoms very clearly and the link between these gut issues and autism.

  2. Nathan says:

    Aah, how does this link in with vaccines causing autism? That’s right: it doesn’t.

    This in no way verifies or repeats wakefield’s study which had only 8 kids in his “study” to which he subjected kids to “conducted unnecessary, invasive tests on children”.


    Have a read and you’ll see that there not only was such a small sample space, he was doing it to boost his own profits as he had a patent on a competing vaccine.

    So to summarise:
    Andrew Wakefield was a fraud, plain and simple. Vaccinations are safe as far as the evidence shows. There is no link between getting your kids a vaccination (that billions of people have had) and developing autism. Preventable deadly diseases are on the rise because people are accepting this discredited information.

    Get your kids vaccinated or our society will be once again at the mercy of preventable diseases. There’s real no reason not to (the minuscule risk of complications pales in comparison to the high risks of the diseases themselves) other than if you want your child to catch a potentially deadly disease that you could have prevented.

    • shotinfo says:

      Hi Nathan – It must be dreadful to go through life so filled with fear of disease! Perhaps you need to do some independent research or your own instead of parroting what others have told you.

      For example, the sample in Wakefield’s original article, you obviously never read it or you would know this, was 12 – not 8 (all of whom are supporting him through this GMC trial). And if you had followed this issue at all, you would know that now, Wakefield’s sample group has grown to over 200 and he is one of dozens and dozens of researchers who have published in peer-reviewed medical journals since that time – all supporting the original hypothesis that vaccination can cause autism in certain susceptible children.

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